Table 5.
Comparisons and correlations of microbiota by cortisol tertiles.
| Group Serum Level in T1 vs. T3, Mean [SD] |
Cortisol (μg/dL) a
7.3 [1.7] vs. 16.6 [2.5] |
p-Value T1 vs. T3 |
q-Value T1 vs. T3 |
Correlations with Cortisol b
(r-coefficient) |
p-Value for Correlations with Cortisol |
|---|---|---|---|---|---|
| Shannon index | 2.35, 2.65 | 0.006 | |||
| Class | |||||
| Erysipelotrichi | 80, 258 | <0.01 | 0.015 | ||
| Gammaproteobacteria | 78, 218 | <0.01 | 0.08 | ||
| Actinobacteria | 0.18 | 0.013 | |||
| Deltaproteobacteria | 0.16 | 0.033 | |||
| Bacilli | 0.15 | 0.041 | |||
| Order | |||||
| Erysipelotrichales | 80, 258 | <0.01 | 0.015 | ||
| Enterobacteriales | 76, 123 | 0.04 | NS | ||
| Bifidobacteriales | 0.16 | 0.028 | |||
| Desulfovibrionales | 0.16 | 0.036 | |||
| Family | |||||
| Erysipelotrichaceae | 80, 258 | <0.01 | 0.015 | ||
| Enterobacteriaceae | 76, 123 | 0.04 | NS | ||
| Prevotellaceae | 284, 523 | 0.06 | NS | ||
| Bacteroidacea | 2291, 1492 | 0.02 | NS | −0.15 | 0.045 |
| Bifidobacteriaceae | 0.16 | 0.028 | |||
| Desulfovibrionaceae | 0.16 | 0.036 | |||
| Genus | |||||
| Veillo; Phascolarctobacterium | 35, 108 | 0.07 | NS | ||
| Erysipelo; Catenibacterium | 29, 198 | <0.01 | 0.041 | ||
| Prevotella; Prevotella | 284, 523 | 0.05 | NS | ||
| Bacteroida; Bacteroides | 2291, 1492 | 0.02 | NS | −0.15 | 0.045 |
| Lachno; Lachnospira | −0.15 | 0.045 | |||
| Bifido; Bifidobacterium | 0.15 | 0.043 | |||
| Species | |||||
| P. stercorea | 53, 126 | 0.03 | NS | ||
| P. copri | 219, 382 | 0.06 | NS |
Data are relative abundance of taxa for taxa with p < 0.10 in at least one analysis. Shannon index of alpha diversity was assessed by pairwise Mann–Whitney test. a Data for participants not taking metformin, p-values are for the lowest tertile (T1) versus the highest tertile (T3). b Correlation coefficients r and p-values are for cortisol adjusted for BMI in the entire group. Abbreviations: NS, not significant; P, Prevotella; T, Tertiles; vs., versus.