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. 2019 Sep 17;17(9):539. doi: 10.3390/md17090539

Figure 3.

Figure 3

Platelet aggregation results in rats at 60 min (n = 5–7) and on the 35th day (n = 9–10) after unfractionated heparin (UFH) and protamine sulfate (PS) administration. (a) Collagen-induced platelet aggregation expressed as the maximal extension (MaxA), (b) the slope of platelet aggregation (Slp), (c) lag time, and (d) area under the curve (AUC). The results are expressed as a percentage of the control samples and are shown as the median (line) with the interquartile range (box), and maximum and minimum values (whiskers). The control values at 60 min were 8.5 (6.0–10.5), 4.0 (3.0–4.5), 156.0 (102.5–199.0), and 20.7 (9.7–25.2), and on the 35th day were 7.0 (3.5–9.0), 4.0 (2.0–5.0), 133.5 (85.0–220.0), and 17.4 (5.4–27.3) for MaxA, Slp, lag time, and AUC, respectively. * p < 0.05 vs. vehicle group; Kruskal–Wallis ANOVA with Dunn’s post-hoc test.