Table 3.

Comparison between the passive separation phenomena.

Method	Hydrodynamic Separation	Hemodynamic Separation	Physical Filtration
Separation criteria	Size	Size, deformability, cells concentration (hematocrit), cell aggregation [102]	Size, shape, deformability
Target sample	Cells, microparticles	RBCs, WBCs, plasma	Cells, particles
Separation Efficiency	Above 90% [90,110]; 80–99% [91]; 62.2% [111]	100% separation efficiency with 15–25% plasma separation volume [65]; 92% separation efficiency with diluted blood (Hct 4.5%) and 37% with whole blood (Hct 45%) [94]	More than 95% of the RBCs and 27% of the WBCs removed from whole blood [105]; 65–100% [102]; 98%, 8% (plasma from whole blood) [112,113]
Throughput	2 mL/min [91]; 106 cells/min [110]; 1.2 mL/h (1010 cells/min) [111]	3–4 µL/min [112]; 5 mL/min [94]	2 × l03 cells/s [112,113]
Potential effects on cells	Shear stress	Shear stress	Clogging, fouling, shear stress
Required instrumentation	Fluidic pumps	Fluidic pumps	Fluidic pumps
Processing layout	Continuous flow	Continuous flow	Batch; Continuous flow