2.
典型哮喘与咳嗽变异型哮喘患者临床特征比较
Clinical features and pulmonary function test results of patients with TAand CVA
| Parameters | TA BDP(+) | TA BPT(+) | CVA | Control group | F | P |
| *P<0.05 vs control group, #P<0.05 vs CVA, ΔP<0.05 vs TA BPT(+),+P<0.05 vs TA BDT(+). Reference value: Zrs/pred<1.50, R5/pred<1.50, R20/ pred<1.50, R5-R20<0.5 kPa·L-1·s-1. CVA: Cough variant asthma. TA BPT(+): Typical asthma with positive bronchial provocation test. TA BDT (+): Typical asthma with positive bronchial dilation test. ACT: Asthma control test. ACQ-7: Asthma control questionnaire-7. FeNO: Fractional exhaled nitric oxide. FVC: Forced vital capacity, FEV1: Forced expiratory Volume in l second; PEF: Peak expiratory flow; MMEF: Maximum midexpiratory flow; MEF: Maximal expiratory flow; Fres: Resonant frequency; Zrs: Respiratory Impedance, R5: Resistance at 5Hz; R20: Resistance at 20 Hz; X5: Reactance at 5 Hz. | ||||||
| Total cases Age (year) | 12 44.33±14.48 | 15 40.93±17.13 | 16 40±16.78 | 27 40.8±14.47 | 0.199 | 0.897 |
| Height (cm) | 161.17±6.88 | 161.80±9.56 | 160.56±6.17 | 164.41±8.01 | 1.014 | 0.392 |
| Weight (Kg) | 58.21±13.93 | 57.60±10.13 | 54.50±11.58 | 61.87±11.75 | 1.377 | 0.258 |
| Interval from onset to diagnosis (month) | 96 (180)# | 48(102) | 24 (42) | - | 8.855 | 0.022 |
| ACT | 15.50±3.34# | 17.27±3.77 | 19.63±2.96 | - | 5.294 | 0.009 |
| ACQ-7 | 2.22±1.10#Δ | 1.49±0.84# | 0.76±0.41Δ+ | - | 11.496 | 0.000 |
| FeNO（ppb） | 63 (43)* | 51 (75)* | 41.5 (51) | 29 (6) | 3.808 | 0.014 |
| FVC%pred (%) | 84.19±22.78*#Δ | 95.71±11.30+ | 102.42±12.59+ | 104.02±12.57 | 5.996 | 0.001 |
| FEV1%pred (%) | 58.58±24.53*#Δ | 90.33±11.36*+ | 95.89±11.39+ | 102.03±11.16 | 26.293 | 0.000 |
| FEV1/FVC (%) | 55.35±12.05*#Δ | 79.08±6.64+ | 78.95±6.36+ | 82.75±8.00 | 32.426 | 0.000 |
| PEF%pred (%) | 59.29±28.07*#Δ | 89.96±14.45+ | 93.21±9.32+ | 95.99±12.98 | 15.412 | 0.000 |
| MMEF%pred (%) | 22.98±11.45*#Δ | 63.12±19.92*+ | 66.80±17.59*+ | 86.02±24.61 | 26.645 | 0.000 |
| MEF75%pred (%) | 36.76±24.04*#Δ | 86.52±19.85*+ | 90.68±14.73*+ | 98.81±28.75 | 31.318 | 0.000 |
| MEF50%pred (%) | 26.07±14.57*#Δ | 67.05±16.69*+ | 74.15±22.20*+ | 94.82±25.37 | 28.832 | 0.000 |
| MEF25%pred (%) | 20.58±7.44*#Δ | 60.20±29.91*+ | 60.15±20.87*+ | 80.20±33.96 | 13.100 | 0.000 |
| Fres (Hz) | 18.79 (12.34)*#Δ | 11.17 (5.18)+ | 12.00 (4.07)+ | 10.80 (5.45) | 12.210 | 0.000 |
| Zrs/pred | 1.82 (1.50)*#Δ | 1.14 (0.25)+ | 1.18 (0.30)+ | 1.07 (0.27) | 12.255 | 0.000 |
| R5/pred | 1.73 (1.46)*#Δ | 1.11 (0.26)+ | 1.13 (0.31)+ | 1.04 (0.25) | 11.184 | 0.000 |
| R20/pred | 1.59 (0.61)*#Δ | 1.14 (0.36)+ | 1.16 (0.30)+ | 1.18 (0.27) | 4.951 | 0.004 |
| R5-R2（0kPa·L-1·s-1） | 0.44 (0.21)*#Δ | 0.33 (0.14)+ | 0.35 (0.07)+ | 0.32 (0.14) | 8.814 | 0.000 |
| X（5 kPa·L-1·s-1） | -0.16 (0.20)*#Δ | -0.10 (0.07)+ | -0.11 (0.06)+ | -0.09 (0.05) | 8.968 | 0.000 |