Table 3.
Genotyping and allele frequency of MALAT1 single nucleotide polymorphisms (SNPs) in hepatocellular carcinoma and normal controls among those aged <55 years.
| Variable | Controls (N = 287) n (%) |
Patients (N = 87) n (%) |
OR (95% CI) | AOR (95% CI) a |
|---|---|---|---|---|
| rs3200401 | ||||
| CC | 193 (67.2%) | 55 (63.2%) | 1.000 (reference) | 1.000 (reference) |
| CT | 82 (28.6%) | 30 (34.5%) | 1.284 (0.768–2.147) | 1.452 (0.837–2.516) |
| TT | 12 (4.2%) | 2 (2.3%) | 0.585 (0.127–2.692) | 0.725 (0.148–3.548) |
| CT + TT | 94 (32.8%) | 32 (36.8%) | 1.195 (0.724–1.971) | 1.364 (0.799–2.330) |
| rs619586 | ||||
| AA | 239 (83.3%) | 82 (94.3%) | 1.000 (reference) | 1.000 (reference) |
| AG | 47 (16.4%) | 5 (5.7%) | 0.310 (0.119–0.806) p = 0.016 * |
0.289 (0.108–0.773) p = 0.013 * |
| GG | 1 (0.3%) | 0 (0%) | NA | NA |
| AG + GG | 48 (16.7%) | 5 (5.7%) | 0.304 (0.117–0.789) p = 0.014 * |
0.286 (0.107–0.765) p = 0.013 * |
| rs1194338 | ||||
| CC | 124 (43.2%) | 36 (41.4%) | 1.000 (reference) | 1.000 (reference) |
| CA | 126 (43.9%) | 42 (48.3%) | 1.148 (0.690–1.911) | 1.313 (0.760–2.266) |
| AA | 37 (12.9%) | 9 (10.3%) | 0.838 (0.370–1.898) | 1.330 (0.548–3.232) |
| CA + AA | 163 (56.8%) | 51 (58.6%) | 1.078 (0.663–1.753) | 1.316 (0.778–2.224) |
The odds ratios (ORs) with their 95% confidence intervals (CIs) were estimated by logistic regression models. a Adjusted for the effects of gender, cigarette smoking, and alcohol consumption. * p value < 0.05 as statistically significant. NA, not applicable; AOR, adjusted odds ratio.