Table 6.
Odds ratio (OR) and 95% confidence interval (CI) of clinical status and MALAT1 rs3200401 genotypic frequencies in hepatocellular carcinoma patients among smokers.
| Variable | Genotypic Frequencies | |||
|---|---|---|---|---|
| CC (%) (n = 100) |
CT + TT (%) (n = 56) |
OR (95% CI) | p Value | |
| Clinical stage | ||||
| Stage III/IV | 34 (34%) | 15 (26.8%) | 0.710 (0.345–1.462) | 0.353 |
| Tumor size | ||||
| >T2 | 34 (34%) | 15 (26.8%) | 0.710 (0.345–1.462) | 0.353 |
| Lymph node metastasis | ||||
| Yes | 5 (5%) | 0 (0%) | NA | NA |
| Distant metastasis | ||||
| Yes | 6 (6%) | 1 (1.8%) | 0.285 (0.033–2.428) | 0.251 |
| Vascular invasion | ||||
| Yes | 18 (18%) | 7 (12.5%) | 0.651 (0.254–1.669) | 0.371 |
| Child–Pugh grade | ||||
| B or C | 19 (19%) | 10 (17.9%) | 0.927 (0.397–2.162) | 0.860 |
| HBsAg | ||||
| Positive | 36 (36%) | 30 (53.6%) | 2.051 (1.055–3.990) | 0.034 * |
| Anti-HCV | ||||
| Positive | 48 (48%) | 23 (41.1%) | 0.755 (0.390–1.463) | 0.405 |
| Liver cirrhosis | ||||
| Positive | 80 (80%) | 50 (89.3%) | 2.083 (0.783–5.542) | 0.141 |
The ORs with their 95% CIs were estimated by logistic regression models. >T2: multiple tumors of >5 cm or tumors involving a major branch of the portal or hepatic vein(s). * p value < 0.05 as statistically significant. NA, not applicable; HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus.