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. 2019 Sep 8;17(9):525. doi: 10.3390/md17090525

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Oligo-fucodian (OF) increases p21 expression and decreases p21 gene methylation in human MG cells. The p21 mRNA (A) and p21 protein (B) levels of U87MG cells were increased after treatment with OF for seven days. The mRNA and protein levels were analyzed by quantitative PCR and Western blot analysis, respectively. (C) Analysis of p21 gene methylation by methylation-specific PCR. PCR products amplified with methylated (M) and unmethylated (U) sequence-specific primers were shown. The quantitative U/M ratios are indicated below each pair of bands. Decitabine was used as positive control.