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. 2019 Sep 8;17(9):525. doi: 10.3390/md17090525

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Combination effects of oligo-fucoidan (OF) and decitabine on the proliferation of MG cells. (A–C) GBM8401, U87MG and immortalized human astroglia (SVGp12) cells were treated with various concentrations of decitabine in combination of OF as indicated for 72 h. The proliferation of cells was measured by sulforhodamine (SRB) assay. Values are expressed as the mean ± standard error of triplicate wells. (D–F) Combination index values of decitabine–OF combinations vs. the inhibition (fraction affected) of cell proliferation. Values lower than 1 show synergistic effects, whereas those equal or close to 1 are additive and those higher than 1 are antagonistic.

Combination effects of oligo-fucoidan (OF) and decitabine on the proliferation of MG cells. (A–C) GBM8401, U87MG and immortalized human astroglia (SVGp12) cells were treated with various concentrations of decitabine in combination of OF as indicated for 72 h. The proliferation of cells was measured by sulforhodamine (SRB) assay. Values are expressed as the mean ± standard error of triplicate wells. (D–F) Combination index values of decitabine–OF combinations vs. the inhibition (fraction affected) of cell proliferation. Values lower than 1 show synergistic effects, whereas those equal or close to 1 are additive and those higher than 1 are antagonistic.