Table 1.
Univariate data analysis results for COPSAC2000 1.
| Metabolite ID | Higher in asthma/wheeze 3 | t-Test p-Value | Mann–Whitney Test p-Value | AUC 4 | |
|---|---|---|---|---|---|
| Rt 2 | Mass | ||||
| 2.38 | 425.0667 m/z | N > Y | 8.1 × 10-11 | 3.9 × 10-7 | 0.849 |
| 1.77 | 215.0312 m/z | N > Y | 1.7 × 10-9 | 1.2 × 10-7 | 0.864 |
| 1.77 | 102.0554 m/z | N > Y | 7.9 × 10-7 | 5.3 × 10-4 | 0.739 |
| 4.98 | 394.1348 m/z | Y > N | 1.2 × 10-5 | 1.0 × 10-3 | 0.726 |
| 2.77 | 278.1021 m/z | Y > N | 1.3 × 10-5 | 9.2 × 10-6 | 0.805 |
| 0.85 | 187.0604 m/z | Y > N | 3.3 × 10-5 | 8.1 × 10-4 | 0.731 |
| 3.87 | 506.2357 n 5 | Y > N | 3.8 × 10-5 | 2.6 × 10-3 | 0.707 |
| 1.92 | 232.0570 m/z | Y > N | 2.0 × 10-4 | 3.6 × 10-3 | 0.700 |
| 0.77 | 266.6361 n | N > Y | 3.1 × 10-4 | 1.9 × 10-4 | 0.757 |
| 0.77 | 615.2553 m/z | N > Y | 6.0 × 10-4 | 6.0 × 10-4 | 0.736 |
| 1.93 | 91.0519 n | Y > N | 6.1 × 10-4 | 4.3 × 10-3 | 0.696 |
| 2.63 | 240.0830 n | N > Y | 6.6 × 10-4 | 1.1 × 10-3 | 0.725 |
| 1.81 | 322.2205 n | Y > N | 8.0 × 10-4 | 3.4 × 10-3 | 0.701 |
| 4.95 | 520.1083 n | N > Y | 8.6 × 10-4 | 1.9 × 10-3 | 0.714 |
| 1.80 | 394.1729 n | Y > N | 9.4 × 10-4 | 1.0 × 10-3 | 0.726 |
| 0.77 | 614.2596 m/z | N > Y | 1.4 × 10-3 | 2.5 × 10-3 | 0.708 |
| 1.92 | 308.1753 n | Y > N | 1.4 × 10-3 | 8.2 × 10-3 | 0.682 |
| 4.95 | 472.0821 n | N > Y | 2.4 × 10-3 | 1.4 × 10-3 | 0.720 |
| 4.95 | 425.0693 m/z | N > Y | 2.9 × 10-3 | 5.5 × 10-3 | 0.691 |
| 1.80 | 417.1577 m/z | Y > N | 4.1 × 10-3 | 6.7 × 10-3 | 0.687 |
| 3.10 | 200.0651 m/z | Y > N | 4.4 × 10-3 | 5.0 × 10-3 | 0.693 |
| 1.90 | 277.1282 m/z | Y > N | 4.7 × 10-3 | 3.1 × 10-3 | 0.703 |
| 1.86 | 376.1704 n | Y > N | 5.8 × 10-3 | 1.1 × 10-3 | 0.725 |
| 1.94 | 249.1164 n | Y > N | 5.9 × 10-3 | 7.4 × 10-3 | 0.684 |
| 1.84 | 384.1464 m/z | Y > N | 1.5 × 10-2 | 6.5 × 10-3 | 0.687 |
| 1.93 | 238.1074 m/z | Y > N | 2.2 × 10-2 | 7.4 × 10-3 | 0.684 |
| 2.34 | 320.0695 n | N > Y | 2.6 × 10-2 | 5.6 × 10-3 | 0.691 |
1 COPSAC2000 is the Copenhagen Prospective Studies on Asthma in Childhood 2000 birth cohort. 2 Rt is retention time. 3 Y > N indicates metabolites that show higher levels in the asthma group than in the non-asthma group, whereas N > Y indicates metabolites showing higher levels in the non-asthma group than in the asthma group. 4 AUC is the area under the ROC curve. 5 The metabolite masses with “n” indicate the neutral mass derived from the sum of relative intensity of some possible adducts, e.g., M+H, M+NH4, M+Na, and M+K, in the peak picking.