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. 2019 Sep 5;9(9):177. doi: 10.3390/metabo9090177

Table 1.

Serum oxylipin concentrations and Alzheimer’s disease (AD) status in overnight-fasted nondiabetic elderly participants.

Metabolites 1 Cognitively Healthy (n = 39) 2 Alzheimer’s Disease (n = 39) 2 P 3 FDR 4 Sub-Class Fatty Acid Precursor
Total Fatty Acid Alcohol 209 (110, 490) 267 (140, 500) 0.295 0.965 Fatty Acid Alcohol -
14-HDoHE 22.9 (8.3, 52) 25.9 (14, 53) 0.376 0.965 Fatty Acid Alcohol C22:6n3
12S-HETE 93.8 (39, 220) 119 (46, 250) 0.386 0.965 Fatty Acid Alcohol C20:4n6
9-HOTE 1.21 (0.82, 2.1) 1.13 (0.81, 1.7) 0.470 0.965 Fatty Acid Alcohol C18:3n3
17-HDoHE 1.72 (1.1, 3.1) 1.91 (1.4, 3.1) 0.471 0.965 Fatty Acid Alcohol C22:6n3
5S-HEPE 0.553 (0.37, 0.93) 0.563 (0.35, 0.75) 0.486 0.965 Fatty Acid Alcohol C20:5n3
11-HETE 1.53 (0.92, 2.2) 1.41 (0.89, 2.1) 0.580 0.965 Fatty Acid Alcohol C20:4n6
13-HOTE 1.96 (1.3, 3) 1.88 (1.4, 2.6) 0.580 0.965 Fatty Acid Alcohol C18:3n3
9-HODE 17.8 (14, 35) 19 (15, 24) 0.643 0.965 Fatty Acid Alcohol C18:2n6
5-HETE 3.72 (2.7, 4.8) 3.75 (3.3, 4.5) 0.668 0.965 Fatty Acid Alcohol C20:4n6
15-HETE 3.1 (2.2, 5.4) 3.68 (2.4, 5) 0.681 0.965 Fatty Acid Alcohol C20:4n6
12S-HEPE 5.72 (2, 12) 5 (2.3, 13) 0.695 0.965 Fatty Acid Alcohol C20:5n3
15-HEPE 0.313 (0.21, 0.65) 0.369 (0.21, 0.56) 0.762 0.965 Fatty Acid Alcohol C20:5n3
9-HEPE 0.235 (0.17, 0.46) 0.268 (0.16, 0.41) 0.824 0.972 Fatty Acid Alcohol C20:5n3
8S-HETE 0.907 (0.62, 1.3) 0.876 (0.68, 1.3) 0.908 0.972 Fatty Acid Alcohol C20:4n6
9-HETE 0.879 (0.61, 1.2) 0.864 (0.61, 1.3) 0.915 0.972 Fatty Acid Alcohol C20:4n6
13S-HODE 26.7 (19, 46) 27.6 (20, 36) 0.957 0.972 Fatty Acid Alcohol C18:2n6
4-HDoHE 0.596 (0.32, 1.1) 0.592 (0.4, 0.89) 0.965 0.972 Fatty Acid Alcohol C22:6n3
14,15-DiHETrE 0.633 (0.51, 0.77) 0.738 (0.64, 0.89) 0.021 0.510 Fatty Acid Diol C18:3n3
11,12-DiHETrE 0.509 (0.41, 0.62) 0.599 (0.46, 0.75) 0.027 0.510 Fatty Acid Diol C20:4n6
5,6-DiHETrE 0.332 (0.23, 0.43) 0.38 (0.3, 0.45) 0.044 0.514 Fatty Acid Diol C20:4n6
8,9-DiHETrE 0.296 (0.23, 0.38) 0.367 (0.29, 0.42) 0.045 0.514 Fatty Acid Diol C20:4n6
LTB4 0.763 (0.49, 1.4) 1.02 (0.68, 1.6) 0.059 0.564 Fatty Acid Diol C20:4n6
19,20-DiHDPE 1.55 (1.3, 2) 1.74 (1.3, 2.6) 0.155 0.930 Fatty Acid Diol -
9,10-DiHODE 0.182 (0.11, 0.27) 0.26 (0.14, 0.34) 0.163 0.930 Fatty Acid Diol C18:3n3
9,10-e-DiHO 5.02 (4.2, 6) 4.92 (4.2, 5.5) 0.437 0.965 Fatty Acid Diol C18:0
17,18-DiHETE 4.97 (2.9, 7.2) 5.41 (3.2, 8.6) 0.448 0.965 Fatty Acid Diol C20:5n3
6-trans-LTB4 0.209 (0.11, 0.29) 0.214 (0.14, 0.35) 0.596 0.965 Fatty Acid Diol C20:4n6
15,16-DiHODE 6.52 (5.2, 9.6) 7.43 (5.5, 11) 0.646 0.965 Fatty Acid Diol C18:3n3
9,10-DiHOME 3.08 (2.5, 4.2) 3.2 (2.5, 4.4) 0.701 0.965 Fatty Acid Diol C18:2n6
Total Fatty Acid Diol 30 (27, 32) 28.3 (24, 36) 0.872 0.972 Fatty Acid Diol -
14,15-DiHETE 0.605 (0.35, 0.92) 0.548 (0.41, 0.81) 0.931 0.972 Fatty Acid Diol C20:5n3
12(13)Ep-9-KODE 5.35 (2, 11) 4.22 (1.6, 9.4) 0.471 0.965 Fatty Acid Epoxide C18:3n3
12(13)-EpOME 2.04 (1.5, 3.1) 2.38 (1.6, 3.2) 0.580 0.965 Fatty Acid Epoxide C18:2n6
Total Fatty Acid Epoxide 15.4 (9.9, 23) 12.5 (8.9, 23) 0.580 0.965 Fatty Acid Epoxide -
9,10-EpO 1.35 (1.1, 1.7) 1.31 (1.1, 1.6) 0.621 0.965 Fatty Acid Epoxide C18:0
19(20)-EpDPE 0.179 (0.14, 0.24) 0.197 (0.14, 0.29) 0.794 0.972 Fatty Acid Epoxide C22:6n3
9(10)-EpOME 0.829 (0.57, 1.2) 0.924 (0.65, 1.4) 0.858 0.972 Fatty Acid Epoxide C18:2n6
15,16-EpODE 1.33 (0.86, 1.9) 1.39 (0.87, 2.2) 0.922 0.972 Fatty Acid Epoxide C18:3n3
Total Fatty Acid Ketone 24.6 (20, 54) 22.8 (14, 31) 0.150 0.930 Fatty Acid Ketone -
9-KODE 14.5 (9.6, 28) 13 (6.9, 20) 0.168 0.930 Fatty Acid Ketone C18:2n6
15-KETE 0.287 (0.18, 0.48) 0.221 (0.15, 0.37) 0.179 0.930 Fatty Acid Ketone C20:4n6
13-KODE 5.87 (3.3, 12) 4.26 (2.2, 8.5) 0.252 0.965 Fatty Acid Ketone C18:2n6
5-KETE 0.342 (0.25, 0.55) 0.36 (0.24, 0.45) 0.574 0.965 Fatty Acid Ketone C20:4n6
9,12,13-TriHOME 3.68 (2.7, 4.3) 3.54 (2.3, 4.7) 0.735 0.965 Fatty Acid Triol C18:2n6
10-Nitrooleate 1.46 (1.1, 2.3) 1.2 (0.88, 1.6) 0.026 0.510 Nitro-fatty Acid C18:1n9
6-keto-PGF1alpha 0.22 (0.2, 0.24) 0.213 (0.19, 0.23) 0.315 0.965 Prostanoid C20:4n6
PGF2alpha 0.422 (0.25, 0.71) 0.518 (0.29, 0.88) 0.507 0.965 Prostanoid C20:4n6
Total Prostanoid 0.745 (0.62, 1.1) 0.816 (0.6, 1.2) 0.714 0.965 Prostanoid -
15-deoxy PGJ2 0.115 (0.11, 0.12) 0.114 (0.11, 0.12) 0.727 0.965 Prostanoid C20:4n6
TXB2 3.24 (0.16, 20) 0.839 (0.2, 14) 0.534 0.965 Thromboid C20:4n6
Total C18:0 species 6.49 (5.3, 7.1) 6.14 (5.6, 6.9) 0.456 0.965 - C18:0
Total C18:2n6 species 73.6 (58, 140) 76.8 (56, 100) 0.574 0.965 - C18:2n6
Total C22:6n3 species 45.3 (26, 98) 37.8 (19, 83) 0.723 0.965 - C22:6n3
Total C20:5n3 species 14.3 (8.9, 26) 13.9 (9, 20) 0.747 0.965 - C20:5n3
Total C20:4n6 species 184 (78, 390) 138 (96, 290) 0.888 0.972 - C20:4n6
Total C18:3n3 species 20.5 (13, 31) 19.3 (14, 28) 0.972 0.972 - C18:3n3

1 Assessed by UPLC-MS/MS. Units are nmol/mL (µM); 2 Values are median (1st quartile, 3rd quartile); 3 Derived from the Mann–Whitney U test; 4 Derived from Benjamini and Hochberg False Discovery Rate (FDR) correction; Bold analytes are significantly different between groups before FDR correction.