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. 2019 Sep 1;9(9):1905–1921.

Figure 1.

Figure 1

Anagrelide (ANA) selectively inhibited growth of cancer cells from different tissues. A. Effects of ANA and ZARD on the growth of different types of cancer cells. The indicated cancer cell lines were cultured with 10 µM ANA or ZARD for 72 h and cell growths were measured by the MTT assay. B. Effects of ANA (100 nM) on the growth of different types of cancer cell lines. 31 indicated cancer cell lines were cultured with 100 nM ANA for 72 h and the cell growths were measured by the MTT assay. C. IC50 values of ANA in the ANA-sensitive cell lines. All data were presented as mean ± s.d. (n = 3). D. Comparison of the effects of PDE3 inhibitors Anagrelide (ANA), Trequinsin (TRE), Cilostamide (CILO) on the growths of the cancer cells. The cells were cultured with the indicated PDE3 inhibitors (1 μM) for 72 h and cell growths were measured by the MTT assay. E. The chemical structures of PDE3 inhibitors.