Figure 3.

Effect of AZD8055 on radiosensitivity of NPC xenografts in mice with IR treatment. A. A photograph of a representative xenograft in each group obtained when the mice were sacrificed 21 days after IR. B. The tumor growth curve of CNE1 cells with different treatments. Varying concentrations of AZD8055 (2.5, 5 and 10 mg/kg/d) alone or combined with IR inhibited tumor growth at different degrees. C. Mean internally measured change in tumor volume ± SEM in each group. D. Tumor nodules were subjected to TUNEL assays. E. Quantitative analysis of TUNEL assay results. AZD8055 combined with IR significantly increased the number of apoptotic cells compared with IR alone. n = 3. The values are depicted as the mean ± SEM; *P < 0.05, and **P < 0.01.