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. 2019 Sep 1;9(9):1938–1956.

Figure 3.

Figure 3

MYCN induces chemoresistance mainly by decreasing drug-induced apoptosis. A, E. Representative dot plots of flow cytometry analyzing the effect of MYCN on early apoptosis and the summary of the cumulative data showing the percentage of early apoptotic cells in MYCN-downregulated SCLC cells (H69AR and H526) after exposure to cytotoxic drugs (ADM, CDDP, and VP16) for 24 h. B, F. Flow cytometry analysis of early apoptosis in MYCN-overexpressing SCLC cells (H69 and H446) induced by exposure to cytotoxic drugs (ADM, CDDP, and VP16) for 24 h. C, D, G, H. Apoptosis-related proteins (BCL2 and BAX) were measured by Western blot in MYCN-downregulated (H69AR and H526) or -upregulated (H69 and H446) SCLC cells after exposure to anticancer drugs for 24 h. Error bars indicate the mean ± SD from three independent experiments. ***, P < 0.001.