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. 2019 Sep 1;9(9):1938–1956.

Figure 6.

Figure 6

MYCN was correlated with poor chemotherapy response and prognosis in SCLC patients. A. Detection of the mRNA expression of MYCN in SCLC tissues and paracancerous lung tissues from the GSE60052 dataset. B. Correlation analysis of the mRNA expression of MYCN and HES1 in the GSE60052 dataset. C. Representative IHC staining of MYCN or HES1 in samples from normal alveolar epithelium and from patients with chemosensitive and refractory SCLC (magnification 400x). D. The MYCN- or HES1-positive expression rate was frequently increased in chemoresistant SCLC tissues compared to chemosensitive SCLC tissues. E. Correlation analysis of MYCN and HES1 by IHC in 42 SCLC patient samples. F. Kaplan-Meier analysis of the overall survival of 42 SCLC patients based on MYCN expression. -, negative; +, positive. Scale bars, 100 μm; Error bars indicate the mean ± SD from three independent experiments. ***P < 0.05.