Figure 5.

DNA vaccine pEKL6 elicits anti-tumor effects on tumor animal models through CD4 T, CD8 T, and NK cells. A. WT mice were immunized with the DNA vaccine pEKL6 twice every for 7 days. Five days after the final immunization, antibodies against NK cells, CD4 T cells, and CD8 T cells were I.V. injected (0.5 mg/mouse) to specifically deplete each cell population. At 7 days after the final immunization, B16-L6 cells (2×10⁴) were injected subcutaneously. Tumor size was measured in 2-3 day intervals in each mouse group. B. The survival rate was observed.