Table 2.
Hazard ratios for liver outcomes by low (30 U/L) and conventional (40 U/L) alanine aminotransferase cut-off values in men and women, estimated using Cox proportional hazard regression analyses and adjusted for age, body mass index, smoking, exercise, alcohol consumption, fasting blood glucose, and cholesterol.
| Events | Men | Women | ||||||
|---|---|---|---|---|---|---|---|---|
| Low ALT (<30) a | Conventional ALT (>40) b | Low ALT (<19) c | Conventional ALT (>40) d | |||||
| HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | |
| Liver-related mortality | 5.18 | (4.04, 6.63) | 6.96 | (5.48, 8.86) | 4.78 | (2.76, 8.27) | 12.06 | (7.43, 19.58) |
| Hepatocellular carcinoma | 1.45 | (1.40, 1.49) | 1.67 | (1.60, 1.74) | 1.12 | (1.08, 1.17) | 1.70 | (1.57, 1.83) |
| Decompensated liver events | 3.42 | (2.95, 3.97) | 4.43 | (3.80, 5.17) | 1.85 | (1.45, 2.35) | 4.29 | (3.17, 5.78) |
a Criteria to distinguish between normal and abnormal. Above 30 is abnormal and below 30 is normal. b Cut-off values of ALT values that discriminate between normal and abnormal in men. Above 40 is abnormal, and below 40 is normal. c Cut-off values of ALT values that discriminate between normal and abnormal in men. Above 19 is abnormal and below 19 is normal. d Cut-off values of ALT values that discriminate between normal and abnormal in men. Above 40 is abnormal and below 40 is normal. ALT: alanine transaminase, HR: Hazard ratios, CI: confidence interval.