Table 1.
Characteristics of the included studies.
| Stearns 2003 [17] | Simon 2013 [19]; Pinkerton 2014 [23] | Capriglione 2016 [21] | |
|---|---|---|---|
| Location | USA | USA | Italy |
| Sample size n. (Treatment/Placebo) | 228 (111/117) | 1174 (585/589) | 80(42/38) |
| Treatment administered | Paroxetine 12.5 mg/day for 6 weeks | Paroxetine 7.5 mg/day for 12 weeks | Paroxetine 7.5 mg/day for 16 weeks |
| Inclusion criteria | Physiologic postmenopausal women with hot flushes and sleep disturbances | Physiologic or surgical postmenopausal women with hot flushes and sleep disturbances | Surgical postmenopausal women with hot flushes and sleep disturbances |
| Mean Age (SD): Treatment Placebo | 56.3 | 54.6 (5.73) | 53.5 (5.71) |
| 56.3 | 54.5 (6.01) | 53.6 (5.01) | |
| Mean BMI (SD): Treatment Placebo | Not available | 28.62 (5.73) | 26.7 (4.62) |
| 29.03 (5.51) | 27.5 (4.71) | ||
| Follow-up | 6 weeks | 12 weeks | 16 weeks |
| Outcomes | Hot flushes reduction; sleep disturbance | Hot flushes reduction; sleep disturbance | Hot flushes reduction; sleep disturbance |
Abbreviations: SD: standard derivation; BMI: body mass index.