Table 2.
Alleles and genotypes frequencies for ESR1 c.454-397T>C (PvuII) polymorphism.
| ESR1 c.397T>C (PvuII) | |||||
|---|---|---|---|---|---|
| Genotype Frequencies (%) | Allele Frequencies (%) | ||||
| TT | TC | CC | T * 1000Genomes: 57.7% |
C * 1000Genomes: 42.3% |
|
| IBD (all patients) n = 198 | 77 (38.9%) | 81 (41.0%) | 40 (20.2%) | 235 (59.3%) | 161 (40.7%) |
| UC patients (n = 98) | 29 (29.6%) | 46 (46.9%) | 23 (23.5%) | 104 (53.1%) | 92 (46.9%) |
| CD patients ** (n = 100) | 48 (48.0%) | 35 (35.0%) | 17 (17.0%) | 131 (65.5%) | 69 (34.5%) |
| CG (n = 41) | 13 (31.7%) | 24 (58.5%) | 4 (9.8%) | 50 (61.0%) | 32 (39.0%) |
| Comparisons of allelic and genotypic frequencies between groups under study | |||||
| [TT + TC] vs. [CC] | [TT] vs. [TC + CC] | [TT] vs. [CC] | [T] vs. [C] | [C] vs. [T] | |
| CG vs. IBD OR, 95% CI P-value |
OR = 0.43 [0.14–1.27] P = 0.116 |
OR = 0.73 [0.36–1.50] P = 0.388 |
OR = 1.69 [0.517–5.516] P = 0.382 |
OR = 1.07 [0.66–1.74] |
OR = 0.93 [0.57–1.52] |
| P = 0.784 | |||||
| CG vs. UC OR, 95% CI P-value |
OR = 0.35 [0.11–1.09] P = 0.062 |
OR = 1.11 [0.50–2.43] P = 0.804 |
OR = 2.58 [0.74–8.97] P = 0.129 |
OR = 1.38 [0.82–2.34] |
OR = 0.72 [0.43–1.22] |
| P = 0.226 | |||||
| CG vs. CD OR, 95% CI P-value |
OR = 0.58 [0.17–1.68] P = 0.273 |
OR = 0.50
[ 0.13–0.70] P = 0.004 |
OR = 1.15 [0.33–4.02] P = 0.825 |
OR = 0.82 [0.48–1.40] |
OR = 1.22 [0.72–2.10] |
| P = 0.472 | |||||
| CD vs. UC OR, 95% CI P-value |
OR = 0.67 [0.33–1.35] P = 0.257 |
OR = 2.20
[ 1.22–3.94] P = 0.008 |
OR = 2.24
[ 1.03–4.88] P = 0.041 |
OR = 1.68
[1.12–2.52] |
OR = 0.60
[ 0.40–0.89] |
| P = 0.012 | |||||
In bold were marked statistically significant results (P-value < 0.05). No corrections for the multiple statistical testing were made. CG—control group, [TT+TC] vs. [CC]—dominant model, risk allele: T, [TT] vs. [TC+CC]—recessive model, risk allele: C, * Allele frequencies for European population according to 1000 Genomes Project have been gathered from https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ss.cgi?ss=ss1322898669 website [41]. ** HWE analysis revealed discordance in CD patients group.