Table 4.

Bone parameters in correlation with ESR1 gene PvuII (c.454-397T>C) and XbaI (c.454-351A>G) genotypes.

Females PvuII	CD (n = 49) Average ± SD				P-Value *	UC (n = 52) Average ± SD			P-Value *
	CC n = 8 (16.3%)	TC n = 24 (49.0%)		TT n = 17 (34.7%)		CC n = 12 (23.1%)	TC n = 25 (48.1%)	TT n = 15 (28.8)
BMI (kg/m2)	20.95 ± 3.66	22.25 ± 4.68		19.46 ± 2.52	0.128	20.49 ± 4.43	21.82 ± 3.82	23.85 ± 4.67	0.086
BMD L2–L4 (g/cm2)	1.13 ± 0.20	1.09 ± 0.17		1.00 ± 0.15	0.127	1.10 ± 0.14	1.18 ± 0.15	1.19 ± 0.16	0.330
L2–L4 T-score	−0.62 ± 1.70	−0.96 ± 1.40		−1.69 ± 1.21	0.133	−0.80 ± 1.14	−0.31 ± 1.11	−0.12 ± 1.31	0.389
L2–L4 Z-score	−0.23 ± 1.32	−0.34 ± 1.38		−0.93 ± 1.03	0.272	−0.14 ± 1.18	0.21 ± 1.08	0.08 ± 1.32	0.697
Femoral neck BMD	0.94 ± 0.15	0.88 ± 0.16		0.77 ± 0.11	0.018	0.87 ± 0.13	0.94 ± 0.13	0.95 ± 0.14	0.269
Femoral neck T-score	−0.37 ± 1.27	−0.83 ± 1.33		−1.73 ± 0.93	0.017	−0.94 ± 1.18	−0.36 ± 1.09	−0.31 ± 1.02	0.274
Femoral neck Z-s	0.07 ± 1.04	−0.23 ± 1.14		−1.09 ± 0.91	0.021 **	−0.30 ± 0.93	0.12 ± 1.09	−0.05 ± 0.90	0.541
Males PvuII	CD (n = 51) Average ± SD				P-Value *	UC (n = 46) Average ± SD			P-Value *
	CC n = 10 (19.6%)	TC n = 35 (68.6%)		TT n = 6 (11.8%)		CC n = 11 (23.9%)	TC n = 21 (45.7%)	TT n = 14 (30.4%)
BMI (kg/m2)	21.28 ± 2.31	21.84 ± 3.66		21.26 ± 3.36	0.694	24.56 ±4.78	25.23 ± 4.19	24.48 ± 2.43	0.819
BMD L2–L4 (g/cm2)	1.11 ± 0.11	1.13 ± 0.19		1.28 ± 0.17	0.127	1.14 ± 0.12	1.18 ± 0.12	1.18 ± 0.16	0.636
L2–L4 T-score	−0.98 ± 0.69	−0.82 ± 1.52		0.40 ± 1.45	0.125	−0.80 ± 1.00	−0.44 ± 1.10	−0.34 ± 1.36	0.653
L2–L4 Z-score	−0.66 ± 0.60	−0.58 ± 1.43		0.62 ± 1.29	0.108	−0.73 ± 0.80	−0.30 ± 1.15	−0.39 ± 1.40	0.408
Femoral neck BMD	1.02 ± 0.07	1.00 ± 0.16		1.14 ± 0.18	0.134	1.05 ± 0.20	1.04 ± 0.12	1.04 ± 0.17	0.993
Femoral neck T-score	−0.33 ± 0.55	−0.42 ± 1.24		0.64 ± 1.29	0.123	−0.13 ± 1.50	−0.22 ± 0.94	0.03 ± 1.56	0.909
Femoral neck Z-score	−0.05 ± 0.56	−0.22 ± 1.05		0.87 ± 1.22	0.101	0.18 ± 1.24	0.11 ± 0.77	0.31 ± 1.48	0.810
Females XbaI	CD (n = 49) Average ± SD				P-Value *	UC (n = 52) Average ± SD			P-Value *
	GG n = 3 (6.1%)	GA n = 24 (49.0%)	AA n = 22 (44.9%)			GG n = 6 (11.5%)	GA n = 25 (48.1%)	AA n = 21 (40.4%)
BMI (kg/m2)	22.09 ± 6.05	21.11 ± 3.49	20.89 ± 4.47		0.758	19.88 ± 2.78	21.19 ± 4.00	23.83 ± 4.55	0.043
BMD L2–L4 (g/cm2)	1.26 ± 0.15	1.08 ± 0.17	1.01 ± 0.16		0.039	1.12 ± 0.06	1.16 ± 0.17	1.18 ± 0.15	0.754
L2–L4 T-score	0.53 ± 1.24	−0.98 ± 1.40	−1.58 ± 1.31		0.035	−0.64 ± 0.54	−0.44 ± 1.25	−0.20 ± 1.22	0.721
L2–L4 Z-score	0.44 ± 1.11	−0.30 ± 1.31	−0.91 ± 1.15		0.104	0.12 ± 0.52	0.17 ± 1.25	0.02 ± 1.19	0.660
Femoral neck BMD	0.97 ± 0.09	0.88 ± 0.16	0.81 ± 0.14		0.152	0.85 ± 0.09	0.93 ± 0.15	0.95 ± 0.13	0.309
Femoral neck T-score	−0.12 ± 0.74	−0.85 ± 1.37	−1.43 ± 1.14		0.127	−1.16 ± 0.93	−0.40 ± 1.23	−0.38 ± 0.94	0.312
Femoral neck Z-score	−0.04 ± 0.35	−0.21 ± 1.15	−0.83 ± 1.11		0.148	−0.29 ± 0.45	0.10 ± 1.23	−0.11 ± 0.79	0.733
Males XbaI	CD (n = 51) Average ± SD				P-Value *	UC (n = 46) Average ± SD			P-Value *
	GG n = 7 (13.7%)	GA n = 27 (53.0%)		AA n = 17 (33.3%)		GG n = 5 (10.9%)	GA n = 22 (47.8%)	AA n = 19 (41.3%)
BMI (kg/m2)	20.91 ± 2.70	21.66 ± 3.64		21.97 ± 3.27	0.582	24.74 ± 7.17	25.13 ± 3.64	24.54 ± 3.10	0.834
BMD L2–L4 [g/cm2]	1.15 ± 0.10	1.12 ± 0.20		1.18 ± 0.18	0.663	1.07 ± 0.13	1.17 ± 0.12	1.19 ± 0.14	0.190
L2–L4 T-score	−0.85 ± 0.77	−0.88 ± 1.62		−0.37 ± 1.32	0.504	−1.20 ± 1.20	−0.57 ± 1.10	−0.23 ± 1.17	0.326
L2–L4 Z-score	−0.58 ± 0.56	−0.58 ± 1.53		−0.19 ± 1.23	0.632	−1.15 ± 0.64	−0.45 ± 1.10	−0.22 ± 1.26	0.230
Femoral neck BMD	1.04 ± 0.05	0.98 ± 0.16		1.08 ± 0.15	0.110	0.98 ± 0.23	1.03 ± 0.13	1.07 ± 0.16	0.484
Femoral neck T-score	−0.22 ± 0.36	−0.56 ± 1.27		0.15 ± 1.17	0.145	−0.58 ± 1.75	−0.26 ± 1.06	0.15 ± 1.36	0.678
Femoral neck Z-score	0.07 ± 0.28	−0.28 ± 1.08		0.25 ± 1.11	0.276	−0.30 ± 1.44	0.06 ± 0.94	0.45 ± 1.21	0.509

In bold are marked statistically significant results (P-value < 0.05). No corrections for the multiple statistical testing were made. * P-value for multiple comparisons, ** Post hoc analysis P-value = 0.041 for [CC]vs[TT].