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. 2019 Aug 22;8(9):1270. doi: 10.3390/jcm8091270

Figure 2.

Figure 2

Three-dimensional network structure of a cancer capillary channel surrounded by human CRC cells. (a) SEM image with lanthanum nitrate of a vessel in normal-appearing mucosa. Right image: High magnification of the left image. Arrowheads indicate 3D mesh-like endothelial glycocalyx (GCX). RBC: Red blood cell. (b) TEM image with lanthanum nitrate of a vessel in normal-appearing mucosa. Arrows indicate moss-like endothelial GCX. RBC: Red blood cell. END: Endothelial cell. (c) SEM image with lanthanum nitrate (left) and guided image (right) showing the relationship between cancer cell nests and capillary vessels in a cross section. Cap: Capillary. (i–iii) High-magnification image (left) and guided image (right) of the rectangles in (i–iii), respectively. Asterisk indicates uncoated capillary wall. (d) A pore of the capillary opened and connected to the network structure composed of the cancer cells themselves in another patient. RBC: Red blood cell. Asterisk: A pore of the capillary.