Table 2.

Panther gene ontology analysis of fly bodies. Gene ontology enrichment analysis of genes upregulated in bodies of GBA1b^m/m flies in comparison to age matched controls. Hyper genomic test was used for the calculation of fold enrichment.

Biological Process	All Known Participating Genes (D. Mel.)	Expected	Observed	Fold Enrichment	p-Value	FDR
Response to external biotic stimulus	363	1.37	18	13.13	1.03 × 10−15	8.04 × 10−12
Response to bacterium	256	0.97	15	15.57	3.88 × 10−14	7.56 × 10−11
Defense response	367	1.39	15	10.82	5.65 × 10−12	8.81 × 10−9
Defense response to Gram-positive bacterium	56	0.21	8	37.82	8.63 × 10−11	1.12 × 10−7
Response to external stimulus	912	3.44	19	5.52	4.18 × 10−10	4.66 × 10−7
Defense response to bacterium	224	0.85	11	13	8.90 × 10−10	8.68 × 10−7
Multi-organism process	1431	5.41	22	4.07	3.10 × 10−9	2.69 × 10−6
Response to stress	1122	4.24	19	4.48	1.24 × 10−8	8.78 × 10−6
Defense response to other organism	291	1.1	11	10.01	1.23 × 10−8	9.61 × 10−6
Humoral immune response	87	0.33	7	21.3	5.60 × 10−8	3.64 × 10−5
Antimicrobial humoral response	72	0.27	6	22.06	4.41 × 10−7	2.64 × 10−4
Immune response	192	0.73	8	11.03	7.30 × 10−7	4.06 × 10−4