Table 3.

Panther gene ontology analysis of fly heads. Gene ontology enrichment analysis of genes upregulated in heads of GBA1b^m/m flies in comparison to age matched controls. Hyper genomic test was used for the calculation of fold enrichment.

Biological Process	All Known Participating Genes (D. Mel.)	Expected	Observed	Fold Enrichment	p-Value	FDR
Antibacterial humoral response	28	0.09	6	68.61	7.99 × 10−10	6.23 × 10−6
Antimicrobial humoral response	72	0.22	7	31.13	4.17 × 10−9	1.08 × 10−5
Immune system process	316	0.99	11	11.14	3.24 × 10−9	1.26 × 10−5
Humoral immune response	87	0.27	7	25.76	1.42 × 10−9	1.59 × 10−5
Response to biotic stimulus	363	1.13	11	9.7	1.31 × 10−8	1.70 × 10−5
Defense response to Gram-positive bacterium	56	0.17	6	34.3	3.42 × 10−8	3.34 × 10−5
Response to bacterium	256	0.8	9	11.26	9.82 × 10−8	8.51 × 10−5
Immune response	192	0.6	8	13.34	1.58 × 10−7	1.23 × 10−4
Defense response	367	1.15	10	8.72	1.75 × 10−7	1.24 × 10−4
Defense response to other organism	291	0.91	9	9.9	2.82 × 10−7	1.83 × 10−4
Defense response to bacterium	224	0.7	8	11.43	4.91 × 10−7	2.95 × 10−4
Response to external stimulus	912	2.85	13	4.56	2.78 × 10−6	1.55 × 10−3
Response to stimulus	2640	8.25	21	2.55	1.14 × 10−5	5.94 × 10−3