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. 2019 Sep 14;8(9):1464. doi: 10.3390/jcm8091464

Figure 4.

Figure 4

Differential effects of free versus SLN-incorporated glucocorticoids on HEI-OC1 viability. Cell viability of HEI-OC1 treated with different concentrations of dexamethasone ((A), grey or pale green), hydrocortisone ((B), grey or pale blue), SLN–DEX ((C), dark green) or SLN–HC ((D), dark blue) over 24 h. The a and b green and blue bars also correspond to the doses tested for dexamethasone or hydrocortisone incorporated into SLN in (C) and (D), respectively. Cell viability was analyzed using the XTT assay as described in the Methods section. Results are shown as mean ± SEM. (A–B) data were obtained from two independent experiments performed in quadruplicate, whereas (C–D) data were obtained from two-four independent experiments performed in quadruplicate. The significance of the differences was evaluated using one-way ANOVA testing; ***p < 0.001.