Table 4.

Results of TBSS analyses comparing the whole brain of the two groups.

Contrast	Voxel Coordinates of Local Maxima (MNI Coordinates)			Side	Voxels	White Matter Tract
	x	y	z			JHU-WM Tractography Atlas	JHU-ICBM-DTI-81 WM Labels
CON > PAT
Fractional anisotropy
	5	–22	–30	R	14	Corticospinal tract	Corticospinal tract
	–53	–11	–22	L	10	Unclassified	Superior longitudinal fasciculus
Radial diffusivity
	–17	–63	–31	L	16	Unclassified	Unclassified
Axial diffusivity
	–10	–47	–29	L	22	Inferior cerebellar peduncle
	48	–24	–17	R	15	Unclassified	Inferior longitudinal fasciculus
PAT > CON
Axial diffusivity
	–51	–31	6	L	11	Unclassified	Superior longitudinal fasciculus

Abbreviations: TBSS, Tract-based spatial statistics; MNI, Montreal Neurological Institute; JHU-WM, the Johns Hopkins University white matter; JHU-ICBM, the Johns Hopkins University-The International Consortium for Brain Mapping; DTI, diffusion tensor imaging; CON, controls; PAT, patients; R, right; L, left. Statistical significance was set at p < 0.001 with a cluster of an extent threshold of k > 10 voxels.