. 2019 Sep 11;8(9):1444. doi: 10.3390/jcm8091444

Table 2.

Amino acid substitutions in PmrA, PmrB, PhoP, and PhoQ in three colistin-heteroresistant K. pneumoniae isolates and their resistant subpopulations.

Isolate^a		Amino Acid Substitutions in:
		PmrA		PmrB		PhoP						PhoQ
		178	203	43	150	163	185	186	198	199	216	152	154	359	414	421	423	429	430
S1703-35	P	Iso	Arg	Glu	Asp	Arg	Arg	Lys	Arg	Lys	Gln	Asp	Lys	Arg	Leu	Asp	Ala	Val	Phe
	RP1		Lys		Asn		Leu	Glu	His	Asn				Lys	Arg		Pro	Ala	Val
	RP2		Lys		Asn			Glu				Asn		Lys			Pro	Ala	Val
S1703-109	P	Ile	Gly	Arg	Asp	Cys	Thr	Gly	Gly	Cys	Gly	Asp	Ser	Lys	Leu	Gly	Pro	Ala	Val
	RP1	Phe		Glu
	RP2			Glu	Asn
S1703-112	P	Ile	Arg			Pro	Leu	Glu	Arg	Lys	Arg	Asp	Gln	Lys	Leu	Gly	Pro	Ala	Val
	RP1		Lys			Arg	Arg				Gln		Lys	Arg
	RP2		Lys			Arg	Arg				Gln		Lys	Arg	Arg

^a P, parental; RP, resistant population. ^b Amino acid alterations that are supposed to be associated with colistin resistance are indicated as white letters with a grey background.