Table 2.
Risks for end-stage renal disease (ESRD), stroke or systemic thromboembolism, acute myocardial infarction (AMI), and mortality among patients with CKD by AF status.
| Outcome | Event | IR (95% CI) | Weighted Time-Dependent Cox Model | |||||
|---|---|---|---|---|---|---|---|---|
| cHR (95% CI) | p-Value | aHR (95% CI) | p-value | aHR (95% CI) | p-Value | |||
| ESRD | ||||||||
| Non-AF | 3440 | 51.84 (50.11–53.57) | 1 | 1 | 0.34 (0.32–0.36) | <0.0001 | ||
| Prevalent AF | 89 | 44.99 (35.64–54.34) | 1.29 (1.22–1.36) | <0.001 | 1.40 (1.32–1.48) | <0.001 | 0.48 (0.45–0.51) | <0.0001 |
| Incident AF | 95 | 85.19 (68.06–102.32) | 3.05 (2.88–3.23) | <0.001 | 2.91 (2.74–3.09) | <0.001 | 1 | |
| Stroke or systemic thromboembolism | ||||||||
| Non-AF | 1247 | 17.04 (16.09–17.98) | 1 | 1 | 0.61 (0.56–0.66) | <0.0001 | ||
| Prevalent AF | 89 | 46.44 (36.79–56.09) | 2.02 (1.88–2.16) | <0.001 | 1.89 (1.77–2.03) | <0.001 | 1.14 (1.05–1.25) | 0.002 |
| Incident AF | 79 | 60.55 (47.19–73.9) | 2.51 (2.33–2.72) | <0.001 | 1.67 (1.54–1.81) | <0.001 | 1 | |
| Acute myocardial infarction | ||||||||
| Non-AF | 461 | 6.08 (5.52–6.63) | 1 | 1 | 0.50 (0.44–0.57) | <0.0001 | ||
| Prevalent AF | 26 | 12.4 (7.64–17.17) | 1.34 (1.18–1.52) | <0.001 | 1.24 (1.09–1.41) | 0.001 | 0.62 (0.53–0.72) | <0.0001 |
| Incident AF | 28 | 19.07 (12.01–26.13) | 3.02 (2.67–3.41) | <0.001 | 1.99 (1.75–2.27) | <0.001 | 1 | |
| All-cause mortality | ||||||||
| Non-AF | 3399 | 44.31 (42.82–45.8) | 1 | 1 | 0.46 (0.44–0.49) | <0.0001 | ||
| Prevalent AF | 219 | 102.1 (88.58–115.62) | 1.83 (1.74–1.92) | <0.001 | 1.64 (1.56–1.72) | <0.001 | 0.76 (0.72–0.81) | <0.0001 |
| Incident AF | 251 | 161.71 (141.7–181.72) | 3.11 (2.96–3.27) | <0.001 | 2.17 (2.06–2.29) | <0.001 | 1 | |
| Cardiovascular mortality | ||||||||
| Non-AF | 452 | 5.89 (5.35–6.44) | 1 | 1 | 0.22 (0.19–0.25) | <0.0001 | ||
| Prevalent AF | 40 | 18.65 (12.87–24.43) | 3.18 (2.83–3.57) | <0.001 | 2.95 (2.62–3.32) | <0.001 | 0.64 (0.57–0.72) | <0.0001 |
| Incident AF | 59 | 38.01 (28.31–47.71) | 6.81 (6.08–7.63) | <0.001 | 4.61 (4.09–5.20) | <0.001 | 1 | |
Confidence interval (CI); hazard ratio (HR); incidence rate (IR; per 1000 person-years); end-stage renal disease (ESRD); acute myocardial infarction (AMI); chronic kidney disease (CKD); atrial fibrillation (F). aHR was calculated from adjustment for all variables in Table 1.