Table 4.
Sensitivity analyses.
| Outcome | Weighted Time-Dependent Cox Model | |||||
|---|---|---|---|---|---|---|
| aHR a (95% CI) | p-Value | aHR b (95% CI) | p-Value | aHR c (95% CI) | p-Value | |
| ESRD | ||||||
| Non-AF | 1 | 1 | ||||
| Prevalent AF | 1.41 (1.33–1.49) | <0.001 | 1.44 (1.36–1.52) | <0.0001 | ||
| Incident AF | 2.85 (2.68–3.02) | <0.001 | 2.90 (2.73–3.08) | <0.0001 | ||
| Stroke | ||||||
| Non-AF | 1 | 1 | ||||
| Prevalent AF | 1.90 (1.77–2.04) | <0.001 | 1.88 (1.75–2.02) | <0.0001 | ||
| Incident AF | 1.86 (1.72–2.02) | <0.001 | 1.82 (1.67–1.97) | <0.0001 | ||
| Acute myocardial infarction | ||||||
| Non-AF | 1 | 1 | ||||
| Prevalent AF | 1.27 (1.11–1.44) | <0.001 | 1.2 (1.05–1.36) | 0.005 | ||
| Incident AF | 2.22 (1.95–2.53) | <0.001 | 2.09 (1.84–2.38) | <0.0001 | ||
| All-cause mortality | ||||||
| Non-AF | 1 | 1 | ||||
| Prevalent AF | 1.71 (1.63–1.80) | <0.001 | 1.72 (1.63–1.80) | <0.0001 | ||
| Incident AF | 2.51 (2.38–2.65) | <0.001 | 2.49 (2.36–2.62) | <0.0001 | ||
| CV mortality | ||||||
| Non-AF | 1 | 1 | ||||
| Prevalent AF | 2.88 (2.56–3.23) | <0.001 | 3.29 (2.91–3.71) | <0.0001 | ||
| Incident AF | 5.08 (4.51–5.72) | <0.001 | 4.6 2(4.10–5.21) | <0.0001 | ||
| Stroke (excluding TIA) | ||||||
| Non-AF | 1 | 1 | 1 | |||
| Prevalent AF | 2.02 (1.88–2.18) | <0.0001 | 1.82 (1.69–1.96) | <0.0001 | 2.02 (1.88–2.17) | <0.0001 |
| Incident AF | 1.87 (1.72–2.03) | <0.0001 | 1.49 (1.36–1.62) | <0.0001 | 1.66 (1.53–1.81) | <0.0001 |
| Stroke (excluding pulmonary embolism) | ||||||
| Non-AF | 1 | 1 | 1 | 1 | ||
| Prevalent AF | 2.10 (1.95–2.26) | <0.0001 | 1.87 (1.73–2.02) | 2.10 (1.95–2.26) | 2.05 (1.91–2.21) | <0.0001 |
| Incident AF | 1.95 (1.79–2.13) | <0.0001 | 1.60 (1.46–1.75) | 1.95 (1.79–2.13) | 1.78 (1.63–1.94) | <0.0001 |
a Adjusted for those variables with a maximum standardization difference >0.10; i.e., age, monthly income, CHA2DS2-VASc score, ischemic heart disease, liver cirrhosis, dementia, beta-blockers, statin, pentoxyfilline, and aspirin/clopidogrel. b Adjusted for all the variables in Table 1 with medications (aspirin/clopidogrel and warfarin) treated as time-dependent variables. c Adjusted for all the variables in Table 1. Transient ischemic attack (TIA).