Figure 3.

(a) Comparison of the tumor volumes from experiment data of the Sutherland and Freyer for EMT6/Ro spheroid [14] and simulation based on the proposed model. In both cases, the tumor is exposed to the unlimited static culture medium, and the glucose and oxygen concentrations in the culture medium are 0.8 mM and 0.28 mM, respectively. (b) Applying the model for HT-29 tumor growth in proliferative phase in a microfluidic device with a microwell trap proposed by Ziółkowska et al. [31]. To better validate the results, on-chip measurements of specific parameters of the HT-29 cell line was necessary. These parameters included the necrosis and apoptosis rates, the diffusion coefficient of the nutrients to the HT-29 tumor spheroids, as well as Michaelis-Menten parameters of the nutrients.