Table 1.

A summary of kinase inhibitors isolated from marine bacteria, 2014–2019.

Compound	Chemical Class	Marine Source	Drug Targets/Inhibitory Activity	References
1	lipopeptide	Bacillus megaterium	p-Akt, p-MAPK, p-GSK-3β	[33]
2 3–5	indolocarbazole alkaloids	Streptomyces sp. A65	inactive analogue PKC, BTK (0.25–1.91 μM)	[34]
6–8	indolocabazole derivatives	Streptomyces sp. A68	PKC-α, BTK, ROCK2 (0.91–1.84 μM)	[35]
9–12	cyclizidine alkaloid	Streptomyces sp. HNA39	ROCK2 (7.0–42 μM)	[36,37,38,39]
13	Indolocarbazole alkaloid indolocarbazole alkaloid indolocarbazole alkaloid	Streptomyces sp. DT-A61	ROCK2 (5.7 nM)	[40]
14		Streptomyces sp. DT-A61	PKC-α (92 nM)	[40]
15		Streptomyces sp. A22	PKC, BTK, ROCK2 (0.91–1.84 μM)	[41]
16 17–21	staurosporine derivatives	Streptomyces sp. NB-A13	inactive analogue PKC-θ (0.06–9.43 μM)	[42]
22	naphthoquinone	Streptomyces sp. XMA39	ROCK2 (>20 μM)	[43]