Table 2.

A summary of kinase inhibitors isolated from marine fungi, 2014–2019.

Compound	Chemical Class	Marine Source	Drug Targets/Inhibitory Activity	References
23	isochromen-6-one	Penicillium sp. ZJ27	PKnG (76.5 μM)	[41]
24	alkaloid	Penicillium sp.	p-p38 MAPK	[45]
25	polyketide	Diaporthe sp. HLY-1	IKK	[46]
26	indole diterpenoid	Aspergillus flavus OUCMDZ-2205.	PKC-β (15.6 μM)	[47]
27	furan derivative	Xylaria sp. (No. 2508)	p-Akt, p-ERK1/2	[48]
28	dihydro-isocoumarin	Aspergillus sp. SF-5976	p-p38 MAPK	[49]
29	phenylspiro-drimane derivative	Stachybotrys sp. KCB13F013	p-ERK, p-JNK, p-p38 MAPK	[50]
30	benzocoumarin	Aspergillus sp. LF660	GSK-3β (0.35 ± 0.04 μM)	[51]
31			GSK-3β (0.13 ± 0.04 μM)
32			GSK-3β (0.20 ± 0.04 μM)
33	lipophilic depsipeptide	Alternaria sp. SF-5016	p-JNK, p-p38 MAPK	[52]
34	citreohybridonol	Toxicocladosporium sp. SF-5699	p-p38 MAPK	[53]
35	2-methyl-hydroquinone	Penicillium sp. HL-85-ALS5-R004	p-Akt, p-ERK1/2	[54]
36	isopyrrolo-naphthoquinone	Biscogniauxia mediterranea	GSK-3β (8.04 μM)	[55]
37	polyketides	Penicillium sp. SF-5629	p-p38 MAPK	[56]
38		Oidiodendron griseum UBOCC-A-114129	CLK1 (15.6 g/mL)	[58]