Table 4.
A summary of kinase inhibitors isolated from marine animals, 2014–2019.
| Compound | Chemical Class | Marine Source | Drug Targets/Inhibitory Activity | References |
|---|---|---|---|---|
| 41–42 | spiroketals | marine ascidian genus Didemnum | CDK5, CK1, DyrK1A, GSK-3 (10 μg/mL) | [62] |
| 43–52 | purine alkaloids | marine tunicate Symplegma rubra | CDK5, CK1, DyrK1A, GSK-3 (10 μg/mL) | [63] |
| 53 | saponin sulfate | sea cucumber | PAK1 (1.2 μM) LIMK (60 μM) AKT (59 μM) |
[64,65] |
| 54 | anthraquinone derivative | marine echinoderm Comanthus sp. | IGF1-R (5 μM) FAK (8.4 μM) EGFR (4 μM) |
[66] |