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. 2019 Jul 25;216(10):2316–2330. doi: 10.1084/jem.20190446

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© 2019 Dosenovic et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 4. — Serum antibody titers. (A) Serum antibody titers against eOD-GT8 and eOD-GT8-KO in 2W1S-primed wild-type mice at 14 d after injection with Env N276D-2W1S or iv8 Fab-2W1S nanoparticles (np) in the presence (left panel) or absence (right panel) of adoptively transferred 3BNC60^SI cells. Merged data from three independent experiments is shown with five to nine mice per group (left panel; n = 18 N276D-2W1S np injected, n = 20 iv8 Fab-2W1S np injected, right panel; n = 5 N276D-2W1S np injected, n = 5 iv8 Fab-2W1S np injected). Lines indicate arithmetic means. Error bars indicate SEM. (B) Serum antibody titers against eOD-GT8 from mice injected as in A at time points between 14 and 124 d after injection. Merged data from two independent experiments. Bars indicate arithmetic mean, and error bars indicate SEM. Merged data from two independent experiments are shown with two to five mice per group in each experiment (n = 10 N276D-2W1S np injected, n = 10 iv8 Fab-2W1S np injected). (C) ELISA using serum from same animals in A, to measure responses to Env N276D (N276D) and Env N276D KO (N276D KO). Statistics in A and C were calculated using the Mann–Whitney U test. **, P ≤ 0.01; ***, P ≤ 0.001; ns, nonsignificant. AUC, area under the curve.