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. 2019 Jul 25;216(10):2316–2330. doi: 10.1084/jem.20190446

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© 2019 Dosenovic et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 7. — Model for an anti-idiotype-prime/Env-boost regimen. (A) An initial pool of B cells including off-target Env-specific B cells (yellow, green, orange, and blue), on-target Env-specific bNAb precursor B cells (purple), off-target anti-idiotypic antibody-specific B cells directed against the multimerization domain and constant regions (gray), and irrelevant B cells (white; left). Activated B cell responses to immunization with an anti-idiotype prime that expands bNAb precursor B cells and B cells that recognize the constant region and multimerization domains of the anti-idiotype (middle). A boost with an Env-derived immunogen specifically expands the bNAb precursor B cells that were preexpanded by the anti-idiotype-prime as well as some off-target Env specific cells (right). (B) The same initial pool of B cells (left) responds to immunization with Env by producing expanded clones of Env-reactive B cells including bNAb precursors and off-target B cells (middle). Boosting with another Env-derived immunogen amplifies both target and off-target B cells (right).