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. 2019 Jul 11;216(10):2231–2241. doi: 10.1084/jem.20180549

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© 2019 Di Luccia et al.

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Figure 1. — Rptor^ΔRorc mice have lower numbers of ILC3 at steady state. (A) Gating strategy of ILC3 subsets in Rptor^ΔRorc and Rptor^fl/fl small intestine lamina propria. (B) Percentages of small intestine lamina propria ILC3 expressing RORγt in Rptor^ΔRorc and Rptor^fl/fl mice (n = 4). (C) Representative FACS plots and numbers of CCR6⁺NKp46⁻, CCR6⁻NKp46⁻ and CCR6⁻NKp46⁺ of RORγt⁺ILC3 in Rptor^ΔRorc and Rptor^fl/fl mice. (D) Fold change in cells producing IL-17A and IL-22 within RORγt⁺ILC3 stimulated with IL-1β + IL-23 ex vivo (n = 4). (E) Representative FACS plots and numbers of ILC1 (NK1.1⁺Eomes⁻) and cNK (NK1.1⁺Eomes⁺) cells in Rptor^ΔRorc and Rptor^fl/fl small intestine lamina propria (n = 4). ns, not significant. Data are pooled from two independent experiments (mean ± SEM; Student's t test; B–E).