Table 2.

Inhibitory effects of the compounds 1–8 on hCA I and hCA II isoenzymes.

	IC50 (µM)			Ki (µM)
Compounds	hCA I	r2	hCA II	r2	hCA I	hCA II
1	58.72	0.9613	40.53	0.9392	70.58 ± 6.67	36.16 ± 13.35
2	33.00	0.9546	45.59	0.9786	38.80 ± 1.93	32.12 ± 6.60
3	47.46	0.9406	48.13	0.9854	30.49 ± 11.26	36.20 ± 10.26
4	29.74	0.9397	45.0	0.9778	30.75 ± 3.49	19.2 ± 2.19
5	69.57	0.9375	48.46	0.9509	63.04 ± 15.45	35.20 ± 8.36
6	52.11	0.9496	30.13	0.9356	37.05 ± 7.77	33.29 ± 6.15
7	40.29	0.9533	29.74	0.9538	52.25 ± 9.97	10.85 ± 2.14
8	57.75	0.9509	18.14	0.9397	28.37 ± 6.63	37.96 ± 2.36
AZA*	16.58	0.9887	8.37	0.9825	30.18 ± 7.77	4.41 ± 0.55

^*Acetazolamide (AZA) was used as a standard inhibitor for both hCA I and II isoenzymes. r²: is a statistical measure of how close the data are to the fitted regression line. It is also known as the coefficient of determination, or the coefficient of multiple determinations for multiple regressions⁵⁹.