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. 2019 Oct 1;32(5):266–277. doi: 10.1089/jamp.2018.1517

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© James Verco et al., 2019. Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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FIG. 5. — Group 3 and 4 H&E and IHC staining. Group 3: H&E staining of adenocarcinoma (A) showing regression highlighted by separation and loss of tumor cells at tumor periphery (blue arrows) and non-neoplastic stroma with inflammation separating the carcinoma into nodules (black arrow). Keratin (AE1/AE3) staining (B) showing positively stained residual carcinoma (blue arrows), original carcinoma border (dashed black line) and residual carcinoma border (continuous black lines). Unstained area (black arrows) represents a large area of tumor loss. CD11b staining (C) showing positively stained immune cell infiltration in areas of tumor regression (black arrows). Residual carcinoma is unstained (blue arrow). Group 4: H&E staining (D) showing no viable adenocarcinoma: complete regression, with organizing inflammation composed of fibrous stroma with admixed lymphocytes and macrophages (black arrow). Lack of positive keratin (AE1/AE3) staining (E) in the same area as image (D) confirms morphologic absence of residual carcinoma (black arrow). CD11b stain (F) showing mild-to-moderate immune cell infiltrate (black arrow).