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. 2019 Aug 22;11(9):427. doi: 10.3390/pharmaceutics11090427

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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¹H NMR spectra of (a) βCD, (b) Mel, (c) 18:1βCDg, and (d) 18:1βCDg-Mel complex at 2:1 molar ratio obtained in D₂O at 298 K. The insets show enlarged resonance regions for the alkenic signal (H11) of the gemini (I) and βCD signals (II). Some signals for the drug (H’₁, H’₂) and the interior and exterior protons of βCD are labeled.