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Physiochemical properties (size and zeta potential) of different melphalan formulations. (--) indicates unmeasurable size or zeta potential. a Results are an average of n ≥ 3 ± standard deviation (SD).
| Componenta | Size nm ± SD |
PDI | Zeta Potential mV ± SD |
|---|---|---|---|
| Mel (1 mM) | -- | -- | -- |
| βCD (2 mM) | -- | -- | -- |
| 18:1βCDg (2 mM) | 170 ± 17 | 0.329 ± 0.047 | +14 ± 3 |
| βCD-Mel (2:1 mole ratio) | -- | -- | -- |
| 18:1βCDg-Mel (2:1 mole ratio) | 160 ± 15 | 0.430 ± 0.04 | +46 ± 2 |
