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. 2019 Sep 1;11(9):443. doi: 10.3390/pharmaceutics11090443

Figure 3.

Figure 3

Colour visualisation of structure differences and similarities in the group of most antitumour evaluated NK1R antagonists (aprepitant, L-733,060 and L-732,138) and in group of CINV indicated NK1R antagonists (aprepitant, rolapinant, casopitant, netupitant and maropitant); the last presented, maropitant, despite the biggest structural distinction, showed high affinity to NK1R and sufficient clinical efficacy.