Table 3.

Organ weights of male BALB/C mice intramuscularly administered the ssRNA nano-structure adjuvant.

		Group 1	Group 2	Group 3	Group 4	Group 5	Group 6
Male
Liver	(g)	1.06 ± 0.11	1.08 ± 0.07	0.99 ± 0.07	0.97 ± 0.04	1.02 ± 0.03	1.25 ± 0.09 *
	(%BW)	4.54 ± 0.45	4.31 ± 0.25	4.14 ± 0.22	4.04 ± 0.05 *	4.26 ± 0.09	4.62 ± 0.16
Spleen	(g)	0.09 ± 0.01	0.10 ± 0.01	0.09 ± 0.01	0.09 ± 0.01	0.10 ± 0.01 *	0.09 ± 0.01
	(%BW)	0.38 ± 0.03	0.39 ± 0.03	0.39 ± 0.05	0.39 ± 0.05	0.44 ± 0.03 *	0.35 ± 0.02
Lung	(g)	0.16 ± 0.01	0.16 ± 0.02	0.17 ± 0.01	0.15 ± 0.01	0.15 ± 0.02	0.15 ± 0.01
	(%BW)	0.67 ± 0.07	0.63 ± 0.07	0.70 ± 0.03	0.63 ± 0.05	0.63 ± 0.08	0.55 ± 0.04 *
Kidney(L)	(g)	0.18 ± 0.02	0.19 ± 0.01	0.19 ± 0.02	0.18 ± 0.01	0.17 ± 0.01	0.21 ± 0.01 *
	(%BW)	0.79 ± 0.08	0.76 ± 0.02	0.79 ± 0.06	0.75 ± 0.03	0.71 ± 0.03	0.76 ± 0.03
Kidney(R)	(g)	0.19 ± 0.02	0.19 ± 0.01	0.19 ± 0.01	0.18 ± 0.01	0.17 ± 0.01	0.21 ± 0.01 *
	(%BW)	0.80 ± 0.09	0.77 ± 0.02	0.81 ± 0.04	0.74 ± 0.03	0.73 ± 0.03	0.77 ± 0.04
Thymus	(g)	0.06 ± 0.01	0.05 ± 0.01	0.04 ± 0.01 *	0.04 ± 0.01 *	0.03 ± 0.01 *	0.04 ± 0.01 *
	(%BW)	0.24 ± 0.05	0.19 ± 0.03	0.17 ± 0.04 *	0.18 ± 0.01 *	0.14 ± 0.01 *	0.15 ± 0.02 *
Brain	(g)	0.43 ± 0.02	0.43 ± 0.02	0.42 ± 0.01	0.43 ± 0.01	0.42 ± 0.03	0.44 ± 0.02
	(%BW)	1.83 ± 0.08	1.70 ± 0.09 *	1.74 ± 0.06	1.78 ± 0.02	1.77 ± 0.13	1.62 ± 0.04 *
Heart	(g)	0.13 ± 0.01	0.15 ± 0.01 *	0.14 ± 0.01	0.13 ± 0.01	0.13 ± 0.01	0.15 ± 0.01 *
	(%BW)	0.58 ± 0.04	0.60 ± 0.04	0.57 ± 0.03	0.54 ± 0.03	0.56 ± 0.02	0.54 ± 0.03
Testis(L)	(g)	0.10 ± 0.01	0.09 ± 0.01	0.10 ± 0.01	0.10 ± 0.01	0.10 ± 0.01	0.09 ± 0.04
	(%BW)	0.44 ± 0.04	0.37 ± 0.04 *	0.42 ± 0.04	0.41 ± 0.03	0.43 ± 0.02	0.33 ± 0.14
Testis(R)	(g)	0.10 ± 0.01	0.11 ± 0.02	0.10 ± 0.01	0.10 ± 0.01	0.10 ± 0.01	0.09 ± 0.04
	(%BW)	0.44 ± 0.05	0.42 ± 0.05	0.44 ± 0.04	0.42 ± 0.02	0.42 ± 0.02	0.33 ± 0.14

The data shown are expressed as the mean ± SD. *p < 0.05, relative to Group 1. Group 1, PBS-control group; Group 2, 1 μg MERS S protein; Group 3, 200 μg ssRNA adjuvant; Group 4, 1 μg MERS S protein and 20 μg ssRNA adjuvant; Group 5, 1 μg MERS S protein and 200 μg ssRNA adjuvant; Group 6, 1 μg MERS S protein and 200 μg ssRNA (recovery group).