. 2019 Sep 1;11(9):439. doi: 10.3390/pharmaceutics11090439

Table 1.

Time-dependent pharmacokinetic modelling of dissolution data to ascertain drug release mechanisms at acidic and physiological pH conditions.

Kinetic Model	Equation
Zero-order	R_t = R₀ + K₀t
First-order	Ln R_t = lnR₀+ K₁t
Higuchi	R_t = K_Ht^1/2
Korsmeyer–Peppas	R_t/R_∞ = K_ktⁿ

K₀, K₁, K_H, and K_k are release rate constants; n is the release exponent (indicative of drug release mechanism); R₀ is the initial amount of 5-FU in the nanocomposite; R_∞ is the total amount of drug dissolved when the dosage form is exhausted; and R_t is the amount of 5-FU released at time t.