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. 2019 Sep 12;11(9):471. doi: 10.3390/pharmaceutics11090471

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Drug model (fluorescent dye DY-676) distribution in human colon carcinoma-bearing nude mice after injection of star-like HPMA-based copolymers containing different spacers—4-(2-oxopropyl)benzoyl (OPB), 4-isopropyl-4-oxobutanoyl (IPB), and 4-oxo-4-(2-pyridyl)butanoyl (PYR) spacers. (Reprinted with permission from [32], Copyright [2017], Elsevier). (B) Release of drug model from the copolymers incubated in phosphate buffered saline at pH 5.0 (●──OPB; ▲──IPB; ▽──PYR) and pH 7.4 (●- - - OPB; ▲- - - IPB; ▽- - - PYR) at 37 °C.

(A) Drug model (fluorescent dye DY-676) distribution in human colon carcinoma-bearing nude mice after injection of star-like HPMA-based copolymers containing different spacers—4-(2-oxopropyl)benzoyl (OPB), 4-isopropyl-4-oxobutanoyl (IPB), and 4-oxo-4-(2-pyridyl)butanoyl (PYR) spacers. (Reprinted with permission from [32], Copyright [2017], Elsevier). (B) Release of drug model from the copolymers incubated in phosphate buffered saline at pH 5.0 (●──OPB; ▲──IPB; ▽──PYR) and pH 7.4 (●- - - OPB; ▲- - - IPB; ▽- - - PYR) at 37 °C.