Figure 10.

(A) In vivo optical imaging. Serial in vivo optical imaging of RAJI tumour-bearing mice injected with linear polymer Pol-Dox/Cy7 (dose 20 mg Dox eq./kg), star polymer Pol(Star)-Dox/Cy7 (dose 7.5 and 10 mg Dox eq./kg) at 3, 5, 8, 11, 18, 25, and 32 days intraperitoneally. Green arrows indicate the position of RAJI tumours; (B) comparison of the fluorescent intensity in the tumor area (left axis) and tumor size measured by the caliper (right axis) for treatment of RAJI-based xenografts with Cyanine7-labelled star-like HPMA-based polymer conjugates with Dox in the dose 7.5 mg/kg. The conjugate was administered i.p. at day 1, when all mice developed palpable s.c. tumors; (□──) tumor size; (■──) fluorescent intensity in tumor area. (Reprinted with permission from [97], Copyright [2017], Elsevier.