Figure 11.

(a) Schematic of an epi-luminescence 2D-fluorescence reflectance imaging system that is commonly used for macroscopic fluorescence imaging applications but suffers from poor resolution and nonlinear signal attenuation in deep tissues. (b) Schematic of FMT systems using ring or planar geometry. Multiple source (red dots) and detector (blue dots) projections are made through the animal, and the fluorescence distribution is calculated by back-projecting physical models of light propagation through tissue. Reprinted from [100]