Table 2.
Overexpressed kinases in ovarian cancer tissue detected by GPL570 microarray. Selected genes showed mean fold induction of ≥3.0, and ≥3.0 fold induction in at least four independent calculations (indicated in bold); p-values are indicated in brackets with 0.00 < 0.005.
| Gene | Probe ID | Fold Induction (p-Value) |
|---|---|---|
| AURKA | 204092_s_at | 13.35 (0.00), 10.85 (0.00), 0.44 (0.09), 0.78 (0.64), 2.75 (0.00), 5.46 (0.00), 7.04 (0.00), 1.19 (0.51), 5.71 (0.00), 2.64 (0.00), 6.3 (0.00), 1.4 (0.55); mean: 4.83 |
| 208079_s_at | 15.46 (0.00), 11.82 (0.00), 0.19 (0.02), 0.62 (0.49), 5.69 (0.00), 6.31 (0.00), 10.27 (0.00), 3.00 (0.00), 16.29 (0.00), 5.25 (0.00), 9.24 (0.00), 1.44 (0.58); mean: 7.13 | |
| BUB1 | 209642_at | 6.24 (0.00), 5.99 (0.00), 0.33 (0.1), 0.73 (0.66), 2.71 (0.00), 6.20 (0.00), 9.43 (0.00), 1.59 (0.04), 4.41 (0.00), 3.36 (0.00), 9.36 (0.00), 1.53 (0.35); mean: 4.32 |
| BUB1B | 203755_at | 10.9 (0.00), 13.95 (0.00), 0.35 (0.05), 1.05 (0.93), 5.62 (0.00), 7.00 (0.00), 10.7 (0.00), 3.02 (0.01), 7.59 (0.00), 6.08 (0.00), 12.09 (0.00), 1.95 (0.32); mean: 6.69 |
| CDC7 | 204510_at | 6.69 (0.00), 6.24 (0.00), 0.45 (0.03), 0.99 (0.98), 1.90 (0.01), 2.77 (0.00), 6.31 (0.00), 1.64 (0.19), 6.25 (0.00), 1.66 (0.05), 6.68 (0.00), 0.80 (0.74); mean: 3.53 |
| CDK1 | 203213_at | 7.03 (0.00), 6.28 (0.00), 0.34 (0.05), 0.93 (0.90), 4.25 (0.00), 8.72 (0.00), 20.02 (0.00), 2.46 (0.04), 8.86 (0.00), 4.31 (0.00), 18.85 (0.00), 2.25 (0.28); mean: 7.02 |
| 210559_s_at | 7.86 (0.00), 6.17 (0.00), 0.32 (0.01), 0.77 (0.54), 2.72 (0.01), 5.69 (0.00), 7.01 (0.00), 1.01 (0.97), 2.77 (0.00), 2.21 (0.05), 7.22 (0.00), 1.44 (0.56); mean: 3.77 | |
| ERBB3 | 226213_at | 0.86 (0.84), 0.98 (0.98), 6.28 (0.00), 7.83 (0.00), 1.11 (0.77), 2.05 (0.04), 3.22 (0.06), 4.85 (0.02), 5.19 (0.02), 1.03 (0.92), 3.20 (0.08), 1.31 (0.63); mean: 3.16 |
| MELK | 204825_at | 6.19 (0.00), 5.44 (0.00), 0.18 (0.00), 0.47 (0.06), 6.84 (0.00), 5.86 (0.00), 11.01 (0.00), 2.56 (0.06), 13.18 (0.00), 5.32 (0.00), 10.77 (0.00), 3.59 (0.13); mean: 5.95 |
| NEK2 | 204641_at | 3.50 (0.02), 2.81 (0.02), 0.66 (0.5), 1.38 (0.62), 5.43 (0.00), 11.06 (0.00), 15.65 (0.00), 4.96 (0.00), 12.01 (0.00), 6.59 (0.00), 17.27 (0.00), 2.59 (0.03); mean: 6.99 |
| PBK | 219148_at | 4.04 (0.00), 4.81 (0.00), 0.14 (0.00), 0.40 (0.16), 2.52 (0.04), 4.23 (0.00), 9.03 (0.00), 0.92 (0.69), 5.38 (0.00), 2.76 (0.03), 7.56 (0.00), 2.05 (0.29); mean: 3.65 |
| PRKX | 204061_at | 0.67 (0.34), 0.69 (0.29), 5.56 (0.00), 3.28 (0.00), 1.39 (0.13), 4.50 (0.00), 5.59 (0.00), 11.54 (0.00), 5.24 (0.02), 1.62 (0.07), 6.23 (0.00), 0.66 (0.23); mean: 3.91 |
| SYK | 226068_at | 1.15 (0.77), 1.25 (0.68), 6.55 (0.00), 6.17 (0.00), 2.41 (0.02), 1.6 (0.19), 4.04 (0.01), 4.52 (0.01), 0.91 (0.86), 2.43 (0.01), 3.19 (0.05), 1.97 (0.12); mean: 3.02 |
| TTK | 204822_at | 7.22 (0.00), 8.01 (0.00), 0.24 (0.03), 1.06 (0.94), 4.87 (0.00), 8.68 (0.00), 11.88 (0.00), 1.74 (0.09), 3.61 (0.01), 3.46 (0.02), 12.12 (0.00), 1.68 (0.31); mean: 5.38 |