Table 2.
The clinical features of CML-BP and BCR-ABL1 positive ALL patients
| Characteristics | CML-BP | BCR-ABL1+ ALL | P value |
|---|---|---|---|
| Number of patients | 17 | 52 | |
| Median Age, y (Range) | 42.9 (15–70) | 39.0 (13–76) | 0.306 |
| Male/Female, % | 52.9/47.1 | 57.7/42.3 | 0.631 |
| Leukocyte count, 109/L (range) | 97.2 (1.0–303) | 57.4 (1.1–308) | 0.131 |
| Hemoglobin, g/L (range) | 82.5 (48–132) | 87.3 (38–149) | 0.630 |
| Thrombocyte count, 109/L (range) | 268.5 (13–2488) | 43.0 (3–230) | 0.000 |
| LDH, U/L (range) | 1059 (98–5490) | 836 (156–5353) | 0.526 |
| Cytogenetic abnormalities, % | 0.684 | ||
| t (9;22) | 4/17 (23.5%) | 11/52 (21.2%) | |
| ACAs | 5/17 (29.4%) | 11/52 (21.2%) | |
| No split phase | 8/17 (47.1%) | 30/52 (57.7%) | |
| BCR-ABL1 FISH | 0.068 | ||
| Complex signal pattern | 9/17 (52.9%) | 16/52 (30.8%) | |
| Typical single pattern | 5/17 (29.4%) | 28/52 (53.8%) | |
| Atypical single pattern | 3/17 (17.6%) | 8/52 (15.4%) | |
| Splenomegaly | 0.000 | ||
| Normal-mild | 8/17 (47.1%) | 51/52 (98.0%) | |
| Moderate- severe | 9/17 (52.9%) | 1/52 (2.0%) |
Abbreviations: CML-BP = chronic myeloid leukemia-blast phase, ALL = acute lymphoblastic leukemia, LDH = Lactate dehydrogenase, ACAs = additional cytogenetic abnormalities, Complex signal pattern = two or more types of BCR-ABL signal patterns, Single pattern = single 1R1G2F fusion signal or other single BCR-ABL fusion signals other than 1R1G2F. Mild splenomegaly: <3 cm under the ribs; Moderate splenomegaly: 3 ~ 6 cm under the ribs; Severe splenomegaly: >6 cm under the ribs