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. 2019 Oct 7;19:264. doi: 10.1186/s12906-019-2673-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — ACT inhibits inflammatory cytokine production in synovial tissue of surgery-stimulated OA rats. SD rats were surgery-stimulated to induce OA and treated with ACT (100 mg/kg, i.p. injection). The generations of (a) IL-1β, (b) IL-6, (c) IL-12, (d) TNF-α and (e) IFN-γ in synovial fluid of knee joint were measured by ELISA assay. ** p < 0.01 and * p < 0.05 compared with sham group. # p < 0.05 compared with OA/NC group. The experiment was repeated three times and the representative results were shown