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Southern blot analysis. Genomic DNA prepared from Notch1[+/+], Notch1[12f/+] and Notch1[12f/12f] progeny of a heterozygous Notch1[12f/+] cross, was digested with HindIII or KpnI, subjected to agarose gel electrophoresis, transferred to membrane and probed with the DNA fragment shown on the diagram of the Notch1[12f] allele. Numbered boxes represent introns. MCS, multiple cloning site of the targeting vector
