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. 2019 Oct 7;19:19. doi: 10.1186/s12861-019-0199-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Morphology of Notch1[12f/12f] embryos. Embryos were obtained at E9.5, E10.5 and E11.5 as described in the legend to Fig. 2 and photographed under an inverted dissecting microscope. Their Theiler stage was determined by comparison of morphological features including number of somites, presence, delimitation and size of forelimb bud and hindlimb bud, branchial arch number and size, shape and size of the heart and head regions, olfactory placode indentation and closure of the otocyst. Other E9.5 and E10.5 embryos are shown in Additional files 1 and 2; Figures S1, S2