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. 2019 Sep 20;218(10):3506–3525. doi: 10.1083/jcb.201807178

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Figure 8. — Perlecan DV regulates pericyte migration through cooperative action of PDGFRβ and integrin α5β1. Schematic model depicting the synergistic action of PDGFRβ and integrin α5β1 in brain pericytes. (A) The up-regulated perlecan attaches to both endothelial cells (EC) and pericytes to maintain the integrity of the BBB. Perlecan interacts with pericytes to promote cell migration, thereby contributing to the repair process of the BBB. (B) In brain pericytes, PDGF-BB stimulation and perlecan DV synergistically induce SHP-2 phosphorylation and downstream FAK phosphorylation, causing a subsequent acceleration of focal adhesion turnover, actin reorganization, and cell migration.